When Pruritus is Not Allergy: Appropriate Signs of Lymphoma and Other Malignancies for the Community Allergist

Authors

  • Amaris K. Balitsky, MD, MSc, FRCPC
  • Gwynivere A. Davies, MD, MPH, FRCPC

DOI:

https://doi.org/10.58931/cait.2023.3139

Abstract

Pruritus is a common symptom that all individuals have experienced at some time. Although general malignancy is a rare cause of pruritus, there is an increased risk of hematologic malignancy in those with chronic itch. For the allergist assessing chronic itch, we have outlined an approach in the case of suspected hematologic malignancy and steps for an initial work-up.

Author Biographies

Amaris K. Balitsky, MD, MSc, FRCPC

Dr. Amaris Balitsky is a malignant hematologist at Juravinski Hospital and Cancer Centre, specializing in lymphoid malignancies and cellular therapy. Her outcomes and health services research focuses on patient-reported outcomes, and short- and long-term toxicities of therapy.

Gwynivere A. Davies, MD, MPH, FRCPC

Dr. Gwynivere Davies is a practicing clinician-educator at McMaster University, and focuses on lymphoma, autologous stem cell transplant and CAR-T in her clinical practice at the Juravinski Hospital and Cancer Centre. Her research interests include the social determinants of health, supported by her MPH from Harvard (2020), health services research and education on the intrinsic roles in the liminal space between residency and independent practice.

References

Rademaker M, Thomas RH, Meyrick Lowe DG, Munro DD. Linear streaking due to bleomycin. Clinical and experimental dermatology. 1987;12(6):457-9.

Weisshaar E, Dalgard F. Epidemiology of itch: adding to the burden of skin morbidity. Acta dermato-venereologica. 2009;89(4):339-50.

Matterne U, Strassner T, Apfelbacher CJ, Diepgen TL, Weisshaar E. Measuring the prevalence of chronic itch in the general population: development and validation of a questionnaire for use in large-scale studies. Acta dermato-venereologica. 2009;89(3):250-6.

Matterne U, Apfelbacher CJ, Vogelgsang L, Loerbroks A, Weisshaar E. Incidence and determinants of chronic pruritus: a population-based cohort study. Acta dermato-venereologica. 2013;93(5):532-7.

Polat M, Öztas P, İlhan MN, Yalçin B, Alli N. Generalized Pruritus. American Journal of Clinical Dermatology. 2008;9(1):39-44.

Paul R, Paul R, Jansen CT. Itch and malignancy prognosis in generalized pruritus: A 6-year follow-up of 125 patients. Journal of the American Academy of Dermatology. 1987;16(6):1179-82.

Fett N, Haynes K, Propert KJ, Margolis DJ. Five-year malignancy incidence in patients with chronic pruritus: A population-based cohort study aimed at limiting unnecessary screening practices. Journal of the American Academy of Dermatology. 2014;70(4):651-8.

Tuckett RP, Wei JY. Response to an itch-producing substance in cat. II. Cutaneous receptor populations with unmyelinated axons. Brain Research. 1987;413(1):95-103.

Greaves MW. Recent advances in pathophysiology and current management of itch. ANNALS-ACADEMY OF MEDICINE SINGAPORE. 2007;36(9):788.

Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, et al. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nature Immunology. 2004;5(7):752-60.

Ishii T, Wang J, Zhang W, Mascarenhas J, Hoffman R, Dai Y, et al. Pivotal role of mast cells in pruritogenesis in patients with myeloproliferative disorders. Blood. 2009;113(23):5942-50.

Gobbi PG, Attardo-Parrinello G, Lattanzio G, Rizzo SC, Ascari E. Severe pruritus should be a B-symptom in Hodgkin’s disease. Cancer. 1983;51(10):1934-6.

Rubenstein M, Duvic M. Cutaneous manifestations of Hodgkin’s disease. International journal of dermatology. 2006;45(3):251-6.

When pruritus is not allergy: appropriate signs of lymphoma and other malignancies for the community allergiest

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Published

2023-05-01

How to Cite

1.
Balitsky AK, Davies GA. When Pruritus is Not Allergy: Appropriate Signs of Lymphoma and Other Malignancies for the Community Allergist. Can Allergy Immunol Today [Internet]. 2023 May 1 [cited 2024 Oct. 18];3(1):5–10. Available from: https://canadianallergyandimmunologytoday.com/article/view/3-1-balitsky_et_al

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