ANCA-Associated Vasculitis For the Allergist and Immunologist

A Clinical Update


  • Mats Junek, MD, MSc, FRCPC Division of Rheumatology, McMaster University; St. Joseph’s Healthcare, Hamilton, ON
  • Nader Khalidi, MD, FRCPC Division of Rheumatology, McMaster University; St. Joseph’s Healthcare, Hamilton, ON



The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides are a group of multisystemic, relapsing, autoimmune diseases that include eosinophilic granulomatosis with polyangiitis (EGPA), granulomatosis with polyangiitis (GPA), and microscopic polyangiitis (MPA). While rare, with incidences between 1 and 25 per 100,000 individuals/year, these are diagnoses that should not be missed, as unrecognized, they are associated with significant morbidity and mortality. Despite their infrequency, international collaborative research has resulted in multiple new therapeutic strategies across all three diseases.

Author Biographies

Mats Junek, MD, MSc, FRCPC, Division of Rheumatology, McMaster University; St. Joseph’s Healthcare, Hamilton, ON

Dr. Mats Junek is a Canadian-Australian Rheumatologist, Vasculitis fellow at McMaster University in Hamilton, and the Vasculitis Clinical Research Consortium/Vasculitis Foundation Vasculitis Fellow. He is concurrently completing the Clinician Investigator Program and a PhD in health research methods at McMaster. The focus of his research is on improving diagnostic methods, evolving improved treatment strategies, and improving our understanding of relapse across small vessel and large vessel vasculitis.

Nader Khalidi, MD, FRCPC, Division of Rheumatology, McMaster University; St. Joseph’s Healthcare, Hamilton, ON

Dr. Nader Khalidi is currently a Professor of Medicine, the Division Director, Rheumatology, and the AbbVie Chair in Education in Rheumatology at McMaster University. He has been successfully involved as an investigator in vasculitis clinical research which includes the Diagnostic and Classification in Vasculitis, Oxford (DCVAS) as well as the Plasma Exchange and Glucocorticoids for treatment of ANCA vasculitis (PEXIVAS), and Mepolizumab in the treatment of eGPA (MIRRA).


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How to Cite

Junek M, Khalidi N. ANCA-Associated Vasculitis For the Allergist and Immunologist: A Clinical Update. Can Allergy Immunol Today [Internet]. 2023 Aug. 31 [cited 2024 May 23];3(2):13–16. Available from: