The use of IVIG for allergy consultants

Authors

  • Bruce D. Mazer, MD McGill University, Montreal, Quebec; Research Institute of the McGill University Health Centre Research Institute; COVID Immunity Task Force

DOI:

https://doi.org/10.58931/cait.2023.3356

Abstract

IgG plays multiple roles in the immune system. Best known as an effector molecule in host defence, infusions of polyclonal IgG have been employed as the mainstay of treatment for patients with immunodeficiency diseases affecting the humoral immune system. IgG preparations are fractionated from pools of several hundred to several thousand donors or more and therefore contain a broad spectrum of antibodies, capable of providing protection against many bacterial and viral diseases. Preparations of human IgG are available for intravenous (IVIG) or subcutaneous (SCIG) administration, allowing individuals with both primary and secondary immune defects to have significantly fewer infections, decreased hospitalizations and overall improved quality of life (QOL). Moreover, IVIG has been employed as a regulator of a large number of autoimmune and inflammatory conditions since the 1980s.

Author Biography

Bruce D. Mazer, MD, McGill University, Montreal, Quebec; Research Institute of the McGill University Health Centre Research Institute; COVID Immunity Task Force

Bruce Mazer Is a Pediatric Allergist and Immunologist and Professor of Medicine at McGill University, Senior Scientist at the Research Institute of the McGill University Health Center and is currently the Associate Scientific Director (Strategy) of Canada’s COVID-19 Immunity Task Force. He is a graduate of McGill’s Faculty of Medicine and Health Sciences and has been a faculty member in the Department of Pediatrics since 1991. From 2000 to 2015, he served as Division Head of Allergy and Immunology at the MCH. In 2015, he was appointed Head of Child Health Research at the Research Institute of the McGill University Health Centre (RI-MUHC). In October 2016, he became Interim Executive Director and Chief Scientific Officer of the RI-MUHC, a role he held until July 2020. He has published over 120 papers and held continuous research funding since 1993. Dr. Mazer’s research focuses on the role of B-cells in regulating inflammation in allergic diseases and antibody responses in immune-deficient patients. His early research on intravenous immunoglobulin influenced the treatment of asthma, Kawasaki disease and immune defects in children. Dr Mazer later led the creation of Canada’s first food allergy consortium which led to multiple food allergy oral immunotherapy trials and genetic biomarkers of food allergy. This CIHR-funded network is generating new insights into life-threatening food reactions and testing new treatments – some based on studies by the Mazer lab. An award-winning mentor who held many leadership positions at McGill, Dr Mazer has played a national role in pandemic-related research as director of scientific strategy for the Canadian COVID-19 Immunity Task Force.

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Published

2023-12-13

How to Cite

1.
Mazer BD. The use of IVIG for allergy consultants. Can Allergy Immunol Today [Internet]. 2023 Dec. 13 [cited 2024 Oct. 7];3(3):5–8. Available from: https://canadianallergyandimmunologytoday.com/article/view/3-3-mazer

Issue

Volume 3, Issue 3, December 2023

Section

Articles