Berotralstat: A data review of a novel oral medication for the treatment of hereditary angioedema

Authors

  • Jason Ohayon, MD, FRCPC McMaster University; HamiltonAllergy.ca

DOI:

https://doi.org/10.58931/cait.2024.4s0161

Abstract

The treatment of hereditary angioedema (HAE) has progressed significantly over the last decade. HAE is an autosomal dominant condition that is bradykinin mediated and affects approximately 1 in 50,000 people. This condition continues to challenge allergists/immunologists (A/I) in promptly managing the disease to reduce attacks of potentially life-threatening angioedema, while improving quality of life in a population in which disease activity tends to increase with age. Notably, delays in diagnosis may reach up to 8 years from initial presentation. The impact of HAE extends beyond the patient, and can affect their caregivers, owing to the fear of acute attacks, which can lead to absenteeism both at school and in the workplace and ultimately negatively impact quality of life and career productivity.

Author Biography

Jason Ohayon, MD, FRCPC, McMaster University; HamiltonAllergy.ca

Dr. Jason Ohayon completed his pediatric residency at McMaster in 1996 and Allergy Clinical Immunology in 1998. He consults in Allergy/ Immunology, for both Children and Adults for the SW Ontario region. He is on staff at Hamilton Health Sciences and St. Joseph’s Hospital and instructs in the Michael DeGroote School of Medicine. Dr. Ohayon’s current clinical interest is in modification of allergic skin and GI disease and in allergic desensitization. Dr. Ohayon serves as a Peer Assessor for the CPSO is a member of the Canadian, American and European Allergy Societies. He is the Research Director of Hamilton Allergy, and co-founder of iCASE Allergy Associates whose mission is to provide practicing Allergists an educative and supportive medium for collaboration. He maintains a private consulting office in West Hamilton.

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Published

2024-01-23

How to Cite

1.
Ohayon J. Berotralstat: A data review of a novel oral medication for the treatment of hereditary angioedema. Can Allergy Immunol Today [Internet]. 2024 Jan. 23 [cited 2024 Apr. 18];4(s01-2):2–8. Available from: https://canadianallergyandimmunologytoday.com/article/view/4-s01-ohayon

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