Venom Immunotherapy in 2025: Practical Insights for Community Allergists
DOI:
https://doi.org/10.58931/cait.2025.5283Abstract
Hymenoptera venom allergy (HVA), caused by stings from bees, wasps, hornets, and yellow jackets, is one of the most common identifiable causes of anaphylaxis in adults. While local reactions are common, systemic responses can be fatal. Venom immunotherapy (VIT) offers long-term protection and is often curative. Introduced in the 1920s, VIT remains the only disease-modifying treatment for HVA.
References
Golden DBK, Wang J, Waserman S, Akin C, Campbell RL, Ellis AK, et al. Anaphylaxis: a 2023 practice parameter update. Ann Allergy Asthma Immunol. 2024;132(2):124–176. doi: 10.1016/j.anai.2023.09.015
Ruëff F, Bauer A, Becker S, Brehler R, Brockow K, Chaker AM, et al. Diagnosis and treatment of Hymenoptera venom allergy: S2k Guideline of the German Society of Allergology and Clinical Immunology (DGAKI) in collaboration with the Arbeitsgemeinschaft für Berufs- und Umweltdermatologie e.V. (ABD), the Medical Association of German Allergologists (AeDA), the German Society of Dermatology (DDG), the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNOKC), the German Society of Pediatrics and Adolescent Medicine (DGKJ), the Society for Pediatric Allergy and Environmental Medicine (GPA), German Respiratory Society (DGP), and the Austrian Society for Allergy and Immunology (ÖGAI). Allergol Select. 2023;7:154–190. doi: 10.5414/ALX02430E
Sturm GJ, Varga EM, Roberts G, Mosbech H, Bilò MB, Akdis CA, et al. EAACI guidelines on allergen immunotherapy: Hymenoptera venom allergy. Allergy. 2018;73(4):744–764. doi: 10.1111/all.13262
Golden DBK, Demain J, Freeman T, Graft D, Tankersley M, Tracy J, et al. Stinging insect hypersensitivity: a practice parameter update 2016. Ann Allergy Asthma Immunol. 2017;118(1):28–54. doi: 10.1016/j.anai.2016.10.031
Floyd ML, Adams KE, Golden DBK. Updates and recent advances on venom immunotherapy. Curr Treat Options Allergy. 2023;1–19. doi: 10.1007/s40521-023-00336-7
Quirt JA, Wen X, Kim J, Herrero AJ, Kim HL. Venom allergy testing: is a graded approach necessary? Ann Allergy Asthma Immunol. 2016;116(1):49–51. doi: 10.1016/j.anai.2015.10.007
Frick M, Fischer J, Helbling A, Ruëff F, Wieczorek D, Ollert M, et al. Predominant Api m 10 sensitization as risk factor for treatment failure in honey bee venom immunotherapy. J Allergy Clin Immunol. 2016;138(6):1663-1671.e9. doi: 10.1016/j.jaci.2016.04.024
Dhami S, Zaman H, Varga EM, Sturm GJ, Muraro A, Akdis CA, et al. Allergen immunotherapy for insect venom allergy: a systematic review and meta-analysis. Allergy. 2017;72(3):342–365. doi: 10.1111/all.13077
McCarty ME, Fajt ML, Gershuni LMS, Petrov AA. A retrospective study of a novel 3-session rush venom immunotherapy protocol. Ann Allergy Asthma Immunol. 2024;133(4):462–468. doi: 10.1016/j.anai.2024.07.013
Poulat J, Bellet-Fraysse E, Touraine F, Coumes-Salomon C, Melloni B, Belle-Moudourou F, et al. Monitoring and stopping Hymenoptera venom immunotherapy: contribution of IgE blocking activity. J Allergy Clin Immunol Glob. 2024;3(4):100329. doi: 10.1016/j.jacig.2024.100329
